Region | Title | System | Version | Edition | Languages | Serial | Status |
| Space-Rat: Xplode! | MAC | | Original | | | |
| Sin Gold SiN Gold | MAC | 1.1.1 | Original | | | |
| Sin Gold SiN Gold | MAC | | MacPlay | | | |
| Sin Gold SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| Spectre VR CD | MAC | | Original | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Sanzennen Shokudou: Shoku Culture Simulation Game 三千年食堂 食カルチャーシミュレーションゲーム | MAC | | Original | | G012JAP-M | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| Syndicate | MAC | | Original | | 7558 | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| The Sims 2: Seasons (Expansion Pack) | MAC | 1.7 | Original | | 11610-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Space Ace CD-ROM (For Macintosh Computers) Don Bluth's Space Ace | MAC | | Original | | | |
| Sangokushi Eiketsuden 三國志英傑伝 | MAC | | Original | | KN10-82104 | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| SimTown: The Town You Build Yourself! シムタウン | MAC | | Original | | MMC-4093 | |
| Star Wars: Screen Entertainment | MAC | | Mac Game Bundle | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | | Original | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | | Original | | | |
| Safecracker | MAC | | Original | | | |
| Sangokushi IV 三國志Ⅳ | MAC | | with Soundware | | KN10571070 | |
| Star Trek: Starfleet Command II: Empires at War: Ad | MAC | | Art Assets | | | |
| Star Trek: New Worlds: Ad | MAC | | Art Assets | | | |
| Seven Kingdoms: Artwork | MAC | | Art Assets | | | |
| Sotsugyou: Graduation 卒業 グラデュエーション | MAC | | Original | | BCRM-0012 | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| SimPeople シムピープル | MAC | | Original, EA Best Selections | | EAM-7020, EAMD-702 | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Sinkha シンカ | MAC | | Original | | IP-085 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| Sexy PK: World Cup-ban セクシー・ピーケー ワールドカップ版 | MAC | | Original | | MMC-4065 | |
| Sid Meier's Colonization | MAC | | Original | | CLMC-60 | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Complete Collection | MAC | 2.9.1 | Original | | 11370-1DDA | |
| Satsui no Shoumei: In the 1st Degree (Disc 2) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078B | |
| Satsui no Shoumei: In the 1st Degree (Disc 1) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078A | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| System Shock | MAC | | Original | | EA 568407 | |
| The Sims | MAC | | | | | |
| Les Sims: Superstar (Disc 2) (Disque Additionnel) | MAC | | Original | | | |
| Les Sims: Superstar (Disc 1) (Disque Additionnel) | MAC | | Original | | | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| The Space Bar (Disc 1) | MAC | 1.0 | Original | | 115-7H | |
| The Space Bar (Disc 3) | MAC | | Original | | 115-7F | |
| The Space Bar (Disc 2) | MAC | | Original | | 115-7E | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| Spider-Man | MAC | | Original | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Dark Forces | MAC | 1.1 | Original | | 3062130 | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| Stellaluna | MAC | | Original | | 2069-1-01 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.0 | Original | | 2052130 | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 3000 | MAC | 1.0.557 | Original | | 1500607 | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault | MAC | 1.01 | Original | | 634630 | |
| Star Wars: Dark Forces | MAC | 1.00 | Original | | | |
| SimCity 2000: CD Collection | MAC | 1.20 | Original | | 1074-029-0601-A | |
| Star Wars: Episode I: Racer | MAC | 1.0 | Original | | | |
| StarCraft | MAC | 1.05 | Original | | S0013318 | |
| StarCraft: Brood War (Expansion Set) | MAC | 1.05 | Original | | S0015019 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630 | |
| Le Secret du Templier | MAC | 1.0 | Covermount | | | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization III Complete | MAC | 1.22 | Original | | 11180-1DDA | |
| Shadow Warrior Lo Wang is Shadow Warrior | MAC | 1.0 | Original | | P/N 7321 | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Star Wars: Dark Forces (Special Edition: 3 Playable Levels) | MAC | 1.2 | LucasArts Macintosh Archives Vol. I, The | | 8022134 | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | MAC | | Original | | S4330250Z12ZZ | |
| The Sims: Vacation (Expansion Pack) | MAC | | Original | | | |
| The Sims | MAC | | | | | |
| Star Trek: Elite Force II (Disc 2) | MAC | | Original | | 10440-2CDA | |
| Star Trek: Elite Force II (Disc 1) | MAC | | Original | | 10440-1CDA | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.01 | Original | | 2052130 | |
| Star Wars: Jedi Knight II: Jedi Outcast | MAC | 1.03 | Original | | 10200-1CDA | |
| Star Wars: Battlefront | MAC | 1.2 | Original | | 10900-1DDA | |
| Star Trek: The Next Generation: Klingon Honor Guard (Install Disk) | MAC | | Original | | P/N 04-17512CD2 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: Knights of the Old Republic | MAC | 1.03 | Original | | 10660-1DDA | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Star Trek: Starfleet Academy (Disc 1) | MAC | 1.1 | Original | | CD-MCR-069-0 | |
| Star Wars: Jedi Knight Gold Pack | MAC | | Original | | 12280-1DDA | |
| Star Wars: Rebel Assault | MAC | 1.06 | LucasArts Macintosh Archives Vol. I, The | | 8022132 | |
| Sinkha | MAC | | Original | | | |
| The Sims 2: Open for Business (Expansion Pack) | MAC | | Original | | 11392-1DDA | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | MAC | 1.0.1 | Original | | 10610-2CDA | |
| Star Trek: Voyager: Elite Force | MAC | | Original | | | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | MAC | 1.0.1 | Original | | 10610-1CDA | |
| Star Fighter | MAC | | | | 03239-001 | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Saikyou Kareshi: Dynamic Darling 最強彼氏 | MAC | | Original | | | |