Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sega Net Mahjong MJ Arcade セガNET麻雀MJ Arcade | SRE | | Original | | DVR-5055D | |
| Sega Racing Classic | SRE | | RingWide | | DVR-0009A | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083D | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083 | |
| Sega Network Taisen Mahjong MJ5 Evolution セガネットワーク対戦麻雀MJ5 EVOLUTION | SRE | | Original | | DVR-0071 | |
| Sega Network Taisen Mahjong MJ5 セガネットワーク対戦麻雀MJ5 | SRE | | Original | | DVR-0027 | |
| Super Shanghai 2005 スーパー上海2005 | NAOMI | 2.001 | Original | | GDL-0031A | |
| Super Shanghai 2005 スーパー上海2005 | NAOMI | 1.001 | Original | | GDL-0031 | |
| Street Fighter Zero 3 Upper | NAOMI | 1.001 | Original | | GDL-0002 | |
| Sports Jam スポーツ・ジャム | NAOMI | 1.005 | Original | | GDS-0003 | |
| Slashout | NAOMI | 1.000 | Original | | GDS-0004 | |
| Shikigami no Shiro II 式神の城II | NAOMI | 1.000 | Original | | GDL-0021 | |
| Senko no Ronde 旋光の輪舞 | NAOMI | 1.001 | Original | | GDL-0030 | |
| StarHorse 2: Final Destination | LINDBERGH | 5.000 | Lindbergh StarHorse 2 | | DVP-0086D | |
| Sega-Race TV セガ-レースTV | LINDBERGH | 1.002 | Lindbergh Yellow | | DVP-0044 | |
| Sega Network Taisen Mahjong MJ4 Evolution セガネットワーク対戦麻雀MJ4 Evolution | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 8.003 | Lindbergh Red EX | | DVP-0049G | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 7.000 | Lindbergh Red EX | | DVP-0049F | |
| Sega Network Taisen Mahjong MJ3 Evolution-you Firmware Koushin Program セガ・ネットワーク対戦麻雀MJ3 EVOLUTION用ファームウェア更新プログラム | CHIHIRO | 1.000 | Original | | GDX-0023 | |
| Sega Network Taisen Mahjong MJ3 Evolution セガ・ネットワーク対戦麻雀MJ3 EVOLUTION | CHIHIRO | 2.000 | Original | | GDX-0021A | |
| Sega Network Taisen Mahjong MJ3 セガ・ネットワーク対戦麻雀MJ3 | CHIHIRO | 5.000 | Original | | GDX-0017D | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 5.000 | Original | | GDX-0006D | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 4.000 | Original | | GDX-0006C | |
| Soulcalibur II ソウルキャリバーⅡ | NS246 | | Original | | SC21 DVD0D | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | Rev A | Original | | GV027-J1 | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | | Original | | GV027-J1 | |
| Session Power Up Kit for DrumMania 2nd Mix / PercussionFreaks 2nd Mix | KS573 | | Original | | 912 *Z A01 | |
| Salaryman Champ: Tatakau Salaryman サラリーマンチャンプ たたかうサラリーマン | KS573 | | Original | | A18 JA A02 | |
| A Survey of Western Art: The Electronic Library of Art | VIS | | Original | | 25-6153 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Sudoku | GAMEWAVE | | Original | | G230 | |
| Space Invaders XL | NUON | | Original | | 11109 | |
| Spider-Man: Angriff der Super-Schurken | VFLASH | | Original | | 093064(GER) | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093143(UK) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Shrek Tercero: ¿Dónde Está Arturo? | VFLASH | | Original | | 093147(SP) | |
| Shrek Le Troisième: En quête d'Artur | VFLASH | | Original | | 093145(FR) | |
| Shrek der Dritte: Die Suche nach Arthus | VFLASH | | Original | | 093144(GER) | |
| Scooby-Doo! Les Civilisations Perdues | VFLASH | | Original | | 093085(FR) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093083(UK) | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo: Viaje al Pasado | VFLASH | | Original | | 093087(SP) | |
| The StrongARM CD-ROM | ARCH | | Original | | | |
| The Soft Rock Software Collection | ARCH | Edition 1 | Original | | | |
| The Soft Rock Games Collection CD | ARCH | | Original | | | |
| Simon the Sorcerer | ARCH | | Original | | | |
| Seashore Life | ARCH | 1.0 | Original | | | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Suteki na Dennou Club すてきな電脳倶楽部 | X68K | | Original | | MKCD-0001 | |
| Sugoi Dennou Club すごい電脳倶楽部 | X68K | | Original | | MKCD-0002 | |
| Secret of Video Architecture X68000画面表示仕様の秘密 | X68K | | Original | | | |
| Surasura Gaikokugo Kaiwa for Pocket PC すらすら外国語会話 for Pocket PC | PPC | | Original | | | |
| Socket Low Power SDIO WLAN | PPC | Release 142 D | Original | | P/N 6210-00142 D | |
| Soccer Addict: 2002 International Cup | PPC | 1.0.3b | Original | | | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| Super Solitaire 15 | PALM | | Rerelease | | 332-0204-10 | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| Sucharaka Salaryman: Deai-kei スチャラカサラリーマン 出会い系 | PALM | | Original | | | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Star Soldier for Palm OS スターソルジャー for Palm OS | PALM | | Original | | HMGOT060015 | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| SimCity for Palm OS Handhelds シムシティー フォーパーム | PALM | 1.5 | Original | | 42-031-003-01 | |
| Shooting Gallery | PALM | | Original | | | |
| Shanghai for Palm 上海 for Palm | PALM | 1.0 | Original | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Snake II | FPP | | Service Release Update 2001 | | 7710117 | |
| Suppin Bishoujo Vol. 3 すっぴん美少女 vol.3 | PHOTO-CD | | Original | | SPN-003 | |
| The Super Model Vol. 1: Gail McKenna ゲイル・マッケンナ | PHOTO-CD | | | | TPS-19011 | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Sumida Yuki: Photo CD Portfolio 墨田ユキ フォトCDポートフォリオ | PHOTO-CD | | Original | | GLS-PH-08 | |
| Steelwood: Private Eye II 名探偵スチールウッドⅡ | PHOTO-CD | | Original | | PX-006 | |
| Steelwood: Private Eye 名探偵スチールウッド | PHOTO-CD | | Original | | PX-001 | |
| Starry the Universe 大宇宙 遥かなる大星雲 | PHOTO-CD | | Original | | PLP-5003 | |
| Space Shuttle スペースシャトル | PHOTO-CD | 1.1 | Original | | C02H | |
| Souzou Sozai: Umi Vol. 1 創造素材 海 Vol.1 | PHOTO-CD | | Original | | SEVI-1049 | |
| Souzou Sozai: Europe no Mado Vol. 2 創造素材 ヨーロッパの窓 Vol.2 | PHOTO-CD | | Original | | ERV2 | |
| Sotsugyou Genga-shuu 卒業原画集 | PHOTO-CD | | Original | | CRMP-1001 | |
| Snowboard "Trick x Trick" スノーボード”トリック×トリック” | PHOTO-CD | | Original | | AS 0003 | |
| Shinpi no Sekai: El Hazard 神秘の世界 エルハザード | PHOTO-CD | | Original | | PIRW-1010 | |
| Shimada Youko: Quatre 島田陽・子カトル | PHOTO-CD | | Original | | FZ-JJ1YP0501 | |
| Shiho Shashin-shuu SHIHO写真集 | PHOTO-CD | | Original | | FZ-JJ1YP0401 | |
| Sexy Bytes: Studio Girls 1 | PHOTO-CD | | Original | | | |
| Sexy Bytes: Rolling Mountains | PHOTO-CD | | Original | | | |
| Sexy Bytes: Outside Dreams | PHOTO-CD | | Original | | | |
| Sexy Bytes: Office Sex | PHOTO-CD | | Original | | | |
| Sexy Bytes: Lacquer & Leather | PHOTO-CD | | Original | | | |
| Sexy Bytes: Housewives 2 | PHOTO-CD | | Original | | | |
| Seikaku Shindan Game: Ukiyo-e Sumo-hen 性格診断ゲーム 浮世絵相撲編 | PHOTO-CD | | Original | | NPCD-1005 | |
| School Mates Collection | PHOTO-CD | | Original | | SJ-0001 | |
| Die Schönsten Hotels der Welt | PHOTO-CD | | Original | | 813 0060 | |
| Schoenbrunn | PHOTO-CD | | Original | | | |
| Sangaku Shashin Photo CD Series Vol. 5: Oze 山岳写真フォトCDシリーズVol.5[尾瀬] | PHOTO-CD | | Original | | AS 0007 | |
| Sangaku Shashin Photo CD Series Vol. 4: Tateyama 山岳写真フォトCDシリーズVol.4[立山] | PHOTO-CD | | Original | | AS 0006 | |
| Sangaku Shashin Photo CD Series Vol. 3: Yatsugatake 山岳写真フォトCDシリーズVol.3[八ケ岳] | PHOTO-CD | | Original | | AS 0005 | |
| Sangaku Shashin Photo CD Series Vol. 2: Hotaka Kamikochi 山岳写真フォトCDシリーズVol.2 穂高・上高地 | PHOTO-CD | | Original | | AS 0004 | |
| Sangaku Shashin Photo CD Series Vol. 1: Shirouma Takeshi Ushiro Tateyama Renpou 山岳写真フォトCDシリーズVol.1 白馬岳・後立山連峰 | PHOTO-CD | | Original | | AS 0001 | |
| Sakura Taisen: Teigeki Secret File サクラ大戦 ~帝劇シークレット・ファイル~ | PHOTO-CD | | Magazine Bundle | | SSMP-00001 | |
| Space Ace | AJCD | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Synthelabo: Cardio-Vasculaire Dausse 1995: Cours de Perfectionnement en Imagerie Cardiaque | CDI | | Original | | | |
| Swiss Click | CDI | | Original | | | |
| SVO: Opleiding voor de Vleessector: Hygiëne en Verse Voeding SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| SVO: Opleiding voor de Vleessector: Het Bewerken van Varkensvlees SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| Surf City | CDI | | Original, Demonstration Disc | | 310-690-131-2, 310690131-2 | |
| Surf City | CDI | 1.07 | Original | | 810 0091 | |
| SuperTest | CDI | 1.03 | Original | | 810 0168 | |
| SuperTest | CDI | 1.01 | Beta | | 810 0168 | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Die Stunde der Patrioten (Disc 2) | CDI | | Original | | 813 1004 | |
| Die Stunde der Patrioten (Disc 1) | CDI | | Original | | 813 1004 | |
| Strip-Poker Pro | CDI | | Original | | 8120142 | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Strip Poker Live | CDI | 1.04 | Original | | 810 0257 | |
| Striker Pro | CDI | | Original, Demonstration Disc | | 310-690-143-2, 310690143-2 | |
| Striker Pro | CDI | 1.14 | Original | | 810 0186, 810 0187, 811 0044 | |
| Stretch-Top System: Wasserbett-Information Stretch-Top System: Waterbed-Information | CDI | | Original | | | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| The Story of Jonah | CDI | 2.04 | Original, FPD | | 310-690-067-2, 310690067-2 | |
| Story Maschine: Märchenzauber | CDI | | Original | | 813 0026 | |
| Story Maschine: Galaxis | CDI | | Original | | 813 0032 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2, 699 025-2 | |
| Stomach in Motion | CDI | | Original | | WIM 060792 | |
| Sting: Ten Summoner's Tales | CDI | 1.03 | Original | | 089 5664 | |
| Stickybear Reading Stickybear Leyendo | CDI | | Original, Demonstration Disc | | 310-690-083-2, 310690083-2, 816 0040 | |
| Stickybear Preschool | CDI | | Pre-Release Demonstration Disc | | 310-690-257-2 | |
| Stickybear Preschool | CDI | | Original, Demonstration Disc | | 310-690-257-2, 310690257-2 | |
| Stickybear Preschool | CDI | 1.05 | Original | | 810 0218 | |
| Stickybear Preschool | CDI | 1.03 | Beta | | 690 2572 | |
| Stickybear Maths | CDI | 1.08 | Original, For Demonstration Only | | 810 0064, 818 0043 | |
| Stickybear Math | CDI | | Original, Demonstration Disc | | 310-690-082-2, 310690082-2 | |
| Stickybear Family Fun | CDI | | Original | | 310690258-2 | |
| Stickybear Family Fun | CDI | | Original | | 810 0237 | |
| Sticks 'n' Fire: Stop That Train | CDI | | Original | | CMC 24020-2CD-I | |
| Stichting voor de Technische Wetenschappen: Jaarverslag 91 Technology Foundation: Annual Report 91 | CDI | | Original | | 2036.001 | |
| Steel Machine | CDI | 1.14 | Original | | 810 0160 | |
| Stars on CD-I: Rob Peetoom | CDI | | Original | | | |
| Stars on CD-i: Ad Peters | CDI | | Original | | | |
| Starring You: BZN Starring You: Zing Mee met Bekende Duetten van BZN | CDI | | Original | | 2700586 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 310690304-2 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 310690304-2 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: Terre Inconnue (Disc 2) | CDI | 1.01 | Original | | 812 1033 | |
| Star Trek VI: Terre Inconnue (Disc 1) | CDI | 1.02 | Original | | 812 1032 | |
| Star Trek VI: Das unentdeckte Land (Disc 2) | CDI | 1.01 | Original | | 813 1024 | |
| Star Trek VI: Das unentdeckte Land (Disc 1) | CDI | 1.04 | Original | | 813 1023 | |
| Standaard Interactieve Encyclopedie | CDI | | Demonstratie-Exemplaar | | 818 0081 | |
| Het Staat in de Sterren | CDI | 1.05 | Original | | 814 0108 | |
| St. Petersbourg et les Trésors de l'Ermitage: The Art of the Czars | CDI | | Original | | 812 0056 | |
| Sport Freaks | CDI | | Original | | 819 1033 | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Space Safari | CDI | 01.08 | Original | | 811 0035 | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Ace | CDI | | Original, Demonstration Disc | | 310-690-059-2, 310690059-2 | |
| Space Ace | CDI | | Original, For Demonstration Only | | 810 0073, 818 0017 | |
| Soundtrap | CDI | 1.06 | Original | | 811 0032 | |
| Somewhere: Une Envie de Naturel: Printemps 96 | CDI | | Original | | | |
| Somewhere: Une Envie de Naturel | CDI | | | | | |
| Solitaire | CDI | | Prototype | | | |
| Solar System | CDI | 1.10 | Original | | 811 0039 | |
| Solar Crusade | CDI | | Original | | SOLARGB5511 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2, 699 011-2, 812 0031 | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| Smilde | CDI | | Original | | | |
| Sliver (Disc 2) | CDI | | Original | | 310690309-2 | |
| Sliver (Disc 1) | CDI | | Original | | 310690309-2 | |
| Skin Style | CDI | | Original | | | |
| Sipa Image: First Image Catalog on CD-I | CDI | | Original | | | |
| Sinnaneun Susjanala 2 신나는숫자나라 2 | CDI | | Original | | ISC 3008 | |
| Simulation Eikaiwa: CD-I Taiken America Ryokou シュミレーション英会話 CD-I体験アメリカ旅行 | CDI | | Original | | | |
| Silhouette: CD-i Demo Version | CDI | | Original | | | |
| Sieben Schritte zum Erfolg II | CDI | | | | | |
| Sieben Schritte zum Erfolg | CDI | | | | | |
| Si Balla! | CDI | 1.03 | Original | | 815 0066 | |
| Si Balla! | CDI | 1.01 | Beta | | 815 0066 | |
| ShowMaster | CDI | 1.0 | Demo | | | |
| Shorelines | CDI | | | | | |
| Shipwreck | CDI | | Original | | 811 0025 | |
| Shark Alert | CDI | | Original, Demonstration Disc | | 310-690-278-2, 310690278-2 | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| Shaolin's Road | CDI | | Original | | SHAOLM24011 | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Sesame Street Moji Asobi: A Visit to Sesame Street: Letters セサミストリート もじあそび | CDI | | Original | | PCIM-00012 | |
| Sesame Street Kazu Asobi: A Visit to Sesame Street: Numbers セサミストリート かずあそび | CDI | | Original | | PCIM-00013 | |
| Serum-Werk Bernburg AG: Veterinärpharmaka: Vol. 1 | CDI | | Original | | | |
| Serie Privélessen: Klassieke Gitaar: Handleiding voor Beginners | CDI | 1.06 | Original | | 814 0067 | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Secrets of Tatjana | CDI | | Original | | 810 0046 | |
| Secret Mission | CDI | | Original | | 814 0133 | |
| Secret Mission | CDI | 1.06 | Original | | 813 0160 | |
| Secret Mission | CDI | 1.07 | Original | | 812 0053 | |
| Secret Mission | CDI | 1.01 | Beta | | 810 0272 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scotland Yard Interactive | CDI | 1.09 | Original | | 813 0042 | |
| Scotland Yard Interactive | CDI | 1.03 | Original | | 810 0139 | |
| Scotland Yard Interactif | CDI | 1.04 | Original | | 812 0070 | |
| Les Schtroumpfs: Le Téléportaschtroumpf | CDI | | Original | | SCHTRFR4011 | |
| Die Schöne und das Tier | CDI | | Original | | 813 0040 | |
| Scan & Teach: Thema 7-12: Klasse 3 | CDI | | Original | | | |
| Scan & Teach: Thema 1-6: Klasse 3 | CDI | | Original | | | |
| Say What You Want | CDI | | Original | | | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| Sargon Chess | CDI | | Original, Original: Longbox | | 310690030-2 | |
| Sargon Chess | CDI | | Original | | 310690030-2, 690 030-2, 690 0302, 699 030-2, 812 0024, 814 0042 | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Sandy's Zirkus Abenteuer | CDI | | Original, For Demonstration Only | | 813 0015 | |
| Sandy's Circus Avontuur | CDI | | Original | | 814 0008 | |
| Sandy's Circus Adventure | CDI | | Original, Demonstration Disc | | 310-690-022-2, 310690022-2, 699 022-2 | |
| Sandy's Circus Adventure | CDI | | Original | | 690 0222 | |
| Salzburger Land | CDI | 1.05 | Original | | 810 0149 | |
| Salvat Enciclopedia Interactiva: Nueva Versión '98 | CDI | L.01.01 | Original | | | |
| Salvat Enciclopedia Interactiva | CDI | | Original | | B-44677-96 | |
| Sälis Cirkus Äventyr | CDI | | Original | | 817 0011 | |
| Sailing | CDI | | Original, Demonstration Disc | | 310-690-101-2, 310690101-2 | |
| Sail to Win! A Rules and Tactics Challenge | CDI | | Original | | 819 0042 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Star Wars: Knights of the Old Republic | MAC | 1.03 | Original | | 10660-1DDA | |
| Star Wars: Jedi Knight Gold Pack | MAC | | Original | | 12280-1DDA | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Battlefront | MAC | 1.2 | Original | | 10900-1DDA | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Complete Collection | MAC | 2.9.1 | Original | | 11370-1DDA | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims 2: Seasons (Expansion Pack) | MAC | 1.7 | Original | | 11610-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Open for Business (Expansion Pack) | MAC | | Original | | 11392-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization III Complete | MAC | 1.22 | Original | | 11180-1DDA | |
| System Shock | MAC | | Original | | EA 568407 | |
| Syndicate | MAC | | Original | | 7558 | |
| Stellaluna | MAC | | Original | | 2069-1-01 | |
| StarCraft: Brood War (Expansion Set) | MAC | 1.05 | Original | | S0015019 | |
| StarCraft | MAC | 1.05 | Original | | S0013318 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.01 | Original | | 2052130 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.0 | Original | | 2052130 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: Screen Entertainment | MAC | | Mac Game Bundle | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | | Original | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | | Original | | | |
| Star Wars: Rebel Assault | MAC | 1.06 | LucasArts Macintosh Archives Vol. I, The | | 8022132 | |
| Star Wars: Rebel Assault | MAC | 1.01 | Original | | 634630 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | MAC | 1.0.1 | Original | | 10610-2CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | MAC | 1.0.1 | Original | | 10610-1CDA | |
| Star Wars: Jedi Knight II: Jedi Outcast | MAC | 1.03 | Original | | 10200-1CDA | |
| Star Wars: Episode I: Racer | MAC | 1.0 | Original | | | |
| Star Wars: Dark Forces (Special Edition: 3 Playable Levels) | MAC | 1.2 | LucasArts Macintosh Archives Vol. I, The | | 8022134 | |
| Star Wars: Dark Forces | MAC | 1.1 | Original | | 3062130 | |
| Star Wars: Dark Forces | MAC | 1.00 | Original | | | |
| Star Trek: Voyager: Elite Force | MAC | | Original | | | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Install Disk) | MAC | | Original | | P/N 04-17512CD2 | |
| Star Trek: Starfleet Command II: Empires at War: Ad | MAC | | Art Assets | | | |
| Star Trek: Starfleet Academy (Disc 1) | MAC | 1.1 | Original | | CD-MCR-069-0 | |
| Star Trek: New Worlds: Ad | MAC | | Art Assets | | | |
| Star Trek: Elite Force II (Disc 2) | MAC | | Original | | 10440-2CDA | |
| Star Trek: Elite Force II (Disc 1) | MAC | | Original | | 10440-1CDA | |
| Star Fighter | MAC | | | | 03239-001 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spider-Man | MAC | | Original | | | |
| Spectre VR CD | MAC | | Original | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | MAC | | Original | | S4330250Z12ZZ | |
| The Space Bar (Disc 3) | MAC | | Original | | 115-7F | |
| The Space Bar (Disc 2) | MAC | | Original | | 115-7E | |
| The Space Bar (Disc 1) | MAC | 1.0 | Original | | 115-7H | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Space Ace CD-ROM (For Macintosh Computers) Don Bluth's Space Ace | MAC | | Original | | | |
| Sotsugyou: Graduation 卒業 グラデュエーション | MAC | | Original | | BCRM-0012 | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| Sinkha | MAC | | Original | | | |
| Sinkha シンカ | MAC | | Original | | IP-085 | |
| SiN Gold | MAC | 1.1.1 | Original | | | |
| SiN Gold | MAC | | MacPlay | | | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SimTown: The Town You Build Yourself! シムタウン | MAC | | Original | | MMC-4093 | |
| The Sims: Vacation (Expansion Pack) | MAC | | Original | | | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| Les Sims: Superstar (Disc 2) (Disque Additionnel) | MAC | | Original | | | |
| Les Sims: Superstar (Disc 1) (Disque Additionnel) | MAC | | Original | | | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| SimPeople シムピープル | MAC | | Original, EA Best Selections | | EAM-7020, EAMD-702 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 3000 | MAC | 1.0.557 | Original | | 1500607 | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | MAC | 1.20 | Original | | 1074-029-0601-A | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Sid Meier's Colonization | MAC | | Original | | CLMC-60 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shadow Warrior Lo Wang is Shadow Warrior | MAC | 1.0 | Original | | P/N 7321 | |
| Sexy PK: World Cup-ban セクシー・ピーケー ワールドカップ版 | MAC | | Original | | MMC-4065 | |
| Seven Kingdoms: Artwork | MAC | | Art Assets | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Le Secret du Templier | MAC | 1.0 | Covermount | | | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Satsui no Shoumei: In the 1st Degree (Disc 2) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078B | |
| Satsui no Shoumei: In the 1st Degree (Disc 1) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078A | |
| Sanzennen Shokudou: Shoku Culture Simulation Game 三千年食堂 食カルチャーシミュレーションゲーム | MAC | | Original | | G012JAP-M | |
| Sangokushi IV 三國志Ⅳ | MAC | | with Soundware | | KN10571070 | |
| Sangokushi Eiketsuden 三國志英傑伝 | MAC | | Original | | KN10-82104 | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Saikyou Kareshi: Dynamic Darling 最強彼氏 | MAC | | Original | | | |
| Safecracker | MAC | | Original | | | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Scooby-Doo! | IXL | 2.0.0 | Original | | R9709 | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Syndicate シンジケート | FMT | | Original | | HMF-163 | |
| Suzaku | FMT | | Original | | HMD-178 | |
| Super Street Fighter II: The New Challengers スーパー・ストリート・ファイターⅡ | FMT | 941011 | CD-ROM-ban (Shokai Gentei: 6-button Pad-tsuki) | | HMF-162 | |
| Super Shooting Towns スーパー・シューティングTOWNS | FMT | | Original | | HMC-191 | |
| Super Shanghai: Dragon's Eye スーパー上海 ~ドラゴンズ・アイ ~ | FMT | | Original | | HMC-181 | |
| Super Real Mahjong PIV スーパーリ・アル麻雀PⅣ | FMT | | Ving Marty Taiou Vol. 7 | | HMF-138 | |
| Super Real Mahjong PII & PIII+ スーパーリアル麻雀 PⅡ&PⅢ+ | FMT | | Ving Marty Taiou Vol. 1 | | HME-111 | |
| Super Real Mahjong PII & PIII スーパー・リアル麻雀PⅡ&PⅢ | FMT | | Ving Vol. 11 | | HMD-126 | |
| Super Odyssey & Dennou Planetarium スーパー・オデッセイ&電脳プラネタリウム | FMT | | Original | | HMA-237 | |
| Super Collection 2: Game Technopolis (IV: Tesera & Hatsukoi Monogatari +) スーパー・コレクション② (Ⅳ~テセラ~&初恋物語+) | FMT | | Original | | HME-184 | |
| Super Collection 1: Game Technopolis (Himitsu no Hanazono & Kimi dake ni Ai o... +) スーパー・コレクション① (秘密の花園&キミだけに愛を…+) | FMT | | Original | | HMD-134 | |
| Suikoden: Tenmei no Chikai 水滸伝・天命の誓い | FMT | | with Soundware | | HMB-108 | |
| Stronghold: Emperor no Yousai ストロングホールド ~皇帝の要塞~ | FMT | | Ving Marty Taiou Vol. 8 | | HMF-133 | |
| Strike Commander Plus ストライク・コマンダーPLUS | FMT | | Original | | | |
| Strike Commander ストライク・コマンダー | FMT | | Original | | HMDC-1915 | |
| Steepia Lite スティーピア ライト | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 34 | | HME-118 | |
| Steepia スティーピア | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 25 | | HMD-179 | |
| StarCruiser II for CD-ROM スタークルーザー Ⅱ for CD‐ROM | FMT | | Original | | JH-006 | |
| SSL Gallery Ver. 1 | FMT | | Original | | | |
| Splatterhouse スプラッターハウス | FMT | | Ving Vol. 13 | | HMD-146 | |
| Speech Trainer V1.0 L10 スピーチ・トレーナー | FMT | | Original | | HMD-224 | |
| Special & Delicious! Original CD-ROM | FMT | | Bundled with Book | | TAIYOU-001 | |
| Space Rogue スペース・ローグ | FMT | | Original | | HMB-180 | |
| Space Museum スペース・ミュージアム | FMT | | Original | | | |
| Sotsugyou: Graduation '93 卒業’93 | FMT | | Original | | JH-002 | |
| Soreike! Anpanman: Tanoshii Eigo Asobi それいけ! アンパンマン ~たのしいえいごあそび~ | FMT | | Original | | FMB-3010 | |
| Software Contest Nyuusen Sakuhinshuu 3 ソフトウェア・コンテスト 入選作品集 3 | FMT | | Original | | HME-200 | |
| Software Contest Nyuusen Sakuhinshuu 2 ソフトウェア・コンテスト 入選作品集 2 | FMT | | Original | | HMD-189 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev B | Original | | HMC-139B | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev A | Original | | HMC-139A | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | | Original | | HMC-139 | |
| Soft de Hard na Monogatari 2 ソフトでハードな物語2 | FMT | | Original | | HMA-214 | |
| Soft de Hard na Monogatari ソフトでハードな物語 | FMT | | Original | | | |
| SimFarm: SimCity's Country Cousin シムファーム | FMT | | Demo | | HMF-920 | |
| SimFarm シムファーム | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 48 | | HMF-170 | |
| SimEarth: The Living Planet シムアース | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 15 | | HMC-141 | |
| SimCity 2000 シム・シティ2000 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 52 | | HMF-191 | |
| SimCity シム・シティ | FMT | Rev A | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121A | |
| SimCity シム・シティ | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121 | |
| SimAnt | FMT | | Original | | HME-104 | |
| Sim Sports Diving: Soreyuke! Diving それゆけ!ダイイビング | FMT | | Original | | HMB-161 | |
| The Silent Service: Chinmoku no Kantai 沈黙の艦隊 | FMT | | Original | | DWFT2802 | |
| Silent Möbius: Case: Titanic サイレント・メビウス | FMT | | Original | | HMC-143 | |
| Sid Meier's Railroad Tycoon レイルロード・タイクーン デラックス | FMT | | Original | | HME-245 | |
| Shuukan Shounen Magazine History 週刊少年マガジンヒストリー | FMT | 1.0 | Original | | HMD-151 | |
| Shougaku Ongaku (5·6-nensei-you) 小学音楽(5·6年生用) | FMT | Rev A | Original | | HMB-512A | |
| Shooting Towns シューティング・タウンズ | FMT | | Original | | HMB-118 | |
| Shinseiki Kouboushi: Dead Force 新世紀興亡史 デッド・フォース | FMT | | Original | | | |
| Shinjuku Labyrinth 新宿ラビリンス | FMT | | Original | | FMSC0030 | |
| Shinc | FMT | | Original | | HME-131 | |
| Shiki o Irodoru: Nihon no Shouka: Natsu 四季を彩る 日本の唱歌 夏 | FMT | | Original | | HMC-102 | |
| Shiki o Irodoru: Nihon no Shouka: Haru 四季を彩る 日本の唱歌 春 | FMT | | Original | | HMC-101 | |
| Shiki o Irodoru: Nihon no Shouka: Fuyu 四季を彩る 日本の唱歌 冬 | FMT | | Original | | HMC-104 | |
| Shiki o Irodoru: Nihon no Shouka: Aki 四季を彩る 日本の唱歌 秋 | FMT | | Original | | HMC-103 | |
| Shijou Saikyou no Video Bible: The Greatest Video Bible in the World 史上最強のビデオバイブル | FMT | | Original | | HMA-251 | |
| Sherlock Holmes: Consulting Detective | FMT | | Demonstration-ban | | HMC-901 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 13 | | HMC-127 | |
| Shangrlia 2 シャングリラ2 | FMT | | Original | | HME-220 | |
| Shanghai 上海 | FMT | | Original | | HMB-192 | |
| Shamhat: The Holy Circlet シャムハト -The Holy Circlet- | FMT | | FM-Towns Sen'you, FM-Towns Marty Sen'you | | DWFS3010, DWFT 3012 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | Rev 1 | Original | | HMC-157 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | | Original | | HMC-157 | |
| Shadow of the Beast II: Juushin no Jubaku シャドー・オブ・ザ・ビーストⅡ ~獣神の呪縛~ | FMT | | Original | | HMD-184 | |
| Sexy in the Hawaii: Nice Gal Hawaii-hen Sexy in The Hawaii ~ナイス・ギャル ハワイ編~ | FMT | | Original | | | |
| Sensual Angels センシャル・エンジェル | FMT | | DCCS (FM Towns Release), PC-9821 Release | | DWDC3813 | |
| Sekigahara 関ヶ原 | FMT | | Original | | HMD-128 | |
| The Secret of Monkey Island モンキー・アイランド | FMT | | Original | | HMD-155 | |
| Secre Volume I: Naoko Iijima SECRE VOLUME ① 「飯島 直子」 | FMT | | Original | | HME-168 | |
| Secre Volume 7: Reiko Chiba SECRE VOLUME ⑦ 「千葉 麗子」 | FMT | | Original | | HME-209 | |
| Secre Volume 6: Reiko Kato SECRE VOLUME ⑥ 「かとう れいこ」 | FMT | | Original | | HME-205 | |
| Secre Volume 5: Tina Gushiken SECRE VOLUME ⑤ 「具志堅 ティナ」 | FMT | | Sample | | HME-204 | |
| Secre Volume 4: Hitomi Fujisaki SECRE VOLUME ④ 「藤崎 仁美」 | FMT | | Original | | HME-196 | |
| Secre Volume 3: Fumie Hosokawa SECRE VOLUME ③ 「細川 ふみえ」 | FMT | | Original | | HME-191 | |
| Secre Volume 2: Mai Oikawa SECRE VOLUME ② 「及川 麻衣」 | FMT | | Original | | HME-180 | |
| Secre Demo Disk | FMT | | Hibaihin | | HME-921 | |
| Schwarzschild IV: The Cradle End シュヴァルツシルトⅣ -THE CRADLE END- | FMT | | Original | | HME-223 | |
| Schwarzschild シュヴァルツシルト | FMT | | Original | | HMC-171 | |
| Scholar Movie Magazine Soukan-gou スコラ MOVIE MAGAZINE 創刊号 | FMT | | Original | | DWDC 4815 | |
| Scavenger 4 スカベンジャー4 | FMT | Rev B | FM Towns Soft Collection Kaigai-hen Vol. 39 | | HME-217B | |
| Scavenger 4 スカベンジャー4 | FMT | Rev A | FM Towns Soft Collection Kaigai-hen Vol. 39 | | HME-217A | |
| Scavenger 4 スカベンジャー4 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 39 | | HME-217 | |
| Scavenger 4 スカベンジャー4 | FMT | | Demo-ban | | HME-918 | |
| Sayonara no Mukougawa さよならの向こう側 | FMT | | Original | | CBF-0008 | |
| Sayaka + Miho 沙也香/美穂 | FMT | | Original | | HMF-179 | |
| Sargon V: World Class Chess サルゴンⅤ | FMT | | Original | | HMD-191 | |
| Sangokushi IV 三國志Ⅳ | FMT | | with Soundware | | HMF-139 | |
| Sangokushi III 三國志Ⅲ | FMT | | with Soundware | | HMD-131 | |
| Sangokushi II 三國志Ⅱ | FMT | | with Soundware | | HMB-159 | |
| Samurai Spirits サムライ・スピリッツ | FMT | | Original | | JH-012 | |
| Sakura no Mori 櫻の杜 | FMT | | PC-9821 Release | | | |
| Shichi Sokusen 死地則戦 | PIPPIN | Rev A | Original | | BDS-20019 | |
| Shuppatsu! Dobutsu Tankentai 出発! どうぶつたんけんたい | QIS | | Original | | BAPD-09 | |
| SD Gundam: Daizukan SDガンダム ~大図鑑~ | QIS | | Original | | BAPD-03 | |
| System Catalog: Kigyou-muke System no Goannai System Catalog 企業向けシステムのご案内 | 3DO | | Hibaihin | | HOU-013DO01 | |
| Syndicate | 3DO | | Original | | | |
| Syndicate シンジケート | 3DO | | Original | | E3D-7025 | |
| Syndicate | 3DO | | Original | | | |
| Syndicate | 3DO | | Bundled with Magazine (Demo) | | | |
| Sword & Sorcery ソード・アンド・ソーサリー | 3DO | | Original | | FZ-SJ0251 | |
| Sword & Sorcery ソード・アンド・ソーサリー | 3DO | | Demo-ban | | FZ-JJ9DSS-5H | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) サプリーム・ウォーリアー | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) サプリーム・ウォーリアー | 3DO | | Original | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| Super Wing Commander 슈퍼 윙 커맨더 | 3DO | | Original | | GDT-GA151 | |
| Super Wing Commander スーパー・ウイング・コマンダー | 3DO | | Original | | FZ-SJ1653 | |
| Super Wing Commander | 3DO | | Original | | R988DCXD | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Demonstration-ban, Bundled with Magazine (4 Character Demo Disc) | | FZ-JJ9DSX-4I | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Original, Power-Up Campaign | | FZ-SJ3851 | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SE3851G | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SE3851 | |
| Super Street Fighter II Turbo | 3DO | | Bundled with Magazine (4 Character Demo Disc) | | | |